Contents
Initial Contributions of Adamantiades and Behget 3 A Historical Review of Adamantiades-Behget's Disease 7 Multicentre Clinical Registries 17 Epidemiology of Behcet's Disease in Asian Countries and Japan 25 F. Kaneko, K. Nakamura, M. Sato, M. Tojo, X. Zheng, and J.-Z. Zhang Recent Epidemiological Data on Behcet's Disease in Iran 31 F. Shahram, F. Davatchi, A. Nadji, A. Jamshidi, H. Chams, C. Chams, N. Shafaie, M. Akbarian, and F. Gharibdoost Prevalence of Behcet's Disease among Iraqis 37 Current...
References Rvy
1. Weber, W.W., and Hein, D.W., 1985, N-acetylation pharmacogenetics. Pharmacol. Rev. 2. Chen, M.L., Lee M.G., and Chiou W.L., 1983, Pharmacokinetics of drugs in blood III Metabolism of procainamide and storage effects of blood samples. J. Pharma. Sci. 72 3. Sharquie, K.E., 1990, Behcet's disease. Postgrad. Doctor Middle East 13 186-190. 4. Behcet, H., 1937, ber rezidivierende aphth se, durch ein virus verursachte Geschw re am Mund am Auge und den Genitalien. Dermatol. Wochenschr. 105...
References Pqb
1. Sakare, T., Takeno, M., Suzuki ,N., et al., 1999, Beh et's Disease. N. Engl. J. Med, 341 1284-1291. 2. Kaklamani, V.G., Vaiolpoulos, G., and Kaklamanis, P.G., 1998, Beh et's Disease. Semin. Arthritis Rheum. 27 197-217. 3. Poulter, L.W., and Lehrer, T. 1989, Immunohistology of oral lesions from patients with recurrent oral ulcers and Beh et's Syndrome. Clin. Exp. Immunol. 78 189-195. 4. International Study Group for Beh et's Disease, 1990, Criteria for diagnosis of Beh et's disease. Lancet...
Antimicrobial Activity of Synthetic Human CAP18 Peptides to Streptococcus
E. ISOGAI , M. HIRATA , H. ISOGAI , K.MATUO amp , K. KIMURA , K.YOKOTA , K. OGUMA , M. TOJO , F. KANEKO , S. KOTAKE , and S. OHNO Health Sciences University of Hokkaido Research Division of Innate Immunity Matsuzono Pharmacy, Sapporo Medical University amp National Institute of advanced Industrial Science and Technology Hokkaido Industrial University Okayama University Fukusima Medical University Hokkaido University, Japan
References Ono
1. Davatchi, F., Shahram, F., Akbarian, M., et al., 1997, Behcet's disease - Analysis of 3443 cases. APLAR J. Rheumatol. 1 2-5. 2. Davatchi, F., 1998, Behcet's disease. In Textbook of Clinical Rheumatology H.S. Howe, and P.H. Feng, eds. , National Arthritis Foundation, Singapore, pp. 298-315. 3. Davatchi, F., Shahram, F., Chams, H., et al., 2001, Long-term outcome of vision in Behcet's disease. Arthritis Rheum. 44 S1309. 4. Davatchi, F., Shahram, F., Chams, H., et al., 2003, The influence of...
Acknowledgments
I take the opportunity to acknowledge the invaluable help and contribution of the members of the Executive Committee of the International Society for Beh et's Disease, in particular Dr. Colin G. Barnes and Prof. Hasan Yazici, the International and National Scientific Committees, the Programme Evaluation Committees, and the Young Investigator Awards and Poster Prize Selection Committees. I am extremely pleased to recognize the charity Deutsches Register Morbus Adamantiades-Beh et e.V., the...
Introduction Fmr
Standard treatment of Behcet's Disease BD comprises immunosuppressive agents such as azathioprine and cyclosporin A in combination with glucocorticosteroids for the more serious manifestations of BD as for example ocular vasculitis, or colchicine for mucocutaneous lesions1. Prognosis of BD is mainly influenced by ocular, neurological or vascular manifestations. Although prognosis has improved by early and aggressive immunosuppressive treatment , many patients have refractory diseases and...
Patients And Methods Owm
Thirty-five 16 male and 19 female Japanese patients with ABD participated at this study after written consent. The patients were recruited during their regular attendance at the ABD Clinic at the Teikyo University Hospital in Tokyo. Of the 35 patients, 22 were classified as complete, and 13 as incomplete ABD, according to the diagnostic criteria proposed by the Behcet's Disease Research Committee of Japan10. Their ages ranged from 40 to 78 mean 59.7 8.1 years, the average duration of the...
Mayo Patients With Complex Aphthosis
The records of 244 patients with complex aphthosis who had been seen personally by the author were evaluated. There were 152 females 62.3 and 92 males 37.7 . The ages ranged from 15 months to 81 years of age. The peak decade was 20-29 years of age. Patients who suffered oral aphthous ulcerations approximately 50 of the time or had continuous oral ulcerations or had oral and genital ulcerations or suffered major disability from aphthosis were included. Causes for aphthosis were sought for each...
Introduction Kvc
It has been well established that HLA-B51 antigen is a genetic marker associated with Beh et's disease BD in several ethnic groups1. However, an increased prevalence of microsatellite polymorphisms located within a 46-kb-segment centromeric of HLA-B gene suggested that other loci situated in this region may be BD susceptibility genes2,3. MICA MHC class I chain-related gene A is a polymorphic gene located within this critical region. Analysis of the triplet repeat polymorphism in its...
Results Wdw
Seventeen patients, thirty-four eyes were included in the study. Ten were males and seven females. The mean-age of the patients at the first consultation in our clinic was 26.3 years ranging from 13 to 41 years . The evolution of non-ocular symptoms before consulting us was 4.7 years ranging between 0.5 and 25 years . The duration of ocular symptoms before consultation was 14.7 months ranging between 1 week and 3 years . At the last visit, the follow up period of the patients was 6.05 years...
Stage 1
In each town in Iraq, there is a main food distribution centre, which distributes food rations every month through some agents in the area using the ration ticket system. The rations of the main food items reach every individual within its family at nominal prices which are supplemented by the state. Mouth ulcer questionnaire was distributed to each family with their food ration. Family members aging 16-45 years were registered, which accounts for 14, 155 persons. The questionnaire inquires for...
References Lhu
1. Davatchi, F., Shahram, F., Akbarian, M., et al., 1997, Behcet's disease - Analysis of 3443 cases. APLAR J. Rheumatol. 1 2-5. 2. Davatchi, F., 1998, Behcet's disease. In Textbook of Clinical Rheumatology H.S. Howe, and P.H. Feng, eds. , National Arthritis Foundation, Singapore, pp. 298-315. 3. Shahram, F., Davatchi, F., Chams, H., et al., 1990, Methotrexate in ocular Behget disease. Preliminary report. In First APLAR Symposium on the Therapy of Rheumatic Diseases, Seoul, Korea. Abstract...
Chemokines In Inflammatory Diseases
Several chronic inflammatory diseases like rheumatoid arthritis, lupus erythematosus, chronic bronchitis, sarcoidosis, and inflammatory bowel disease have been studied more extensively than Behcet's disease. Immunochemical and cytofluorimetric analysis of tissues, exudates, and body fluids highlights the role of chemokines in the pathological process, and the patterns of expression of chemokines and receptors reflect the peculiarities of the underlying disease. Disease models in wild-type and...
Materials And Methods 1
Between 1995 and 2000, 32 patients of German and 33 patients of Turkish origin living in Germany were evaluated with respect to the entire spectrum of disease manifestations, HLA associations, gender, age at manifestation, and time by diagnosis. All patients fulfilled the International Study Group Criteria8. Patients were interviewed by two rheumatologists IK, IG , one of them also speaking Turkish IG concerning the occurrence of any of the symptoms and the time at which the respective...
References Syc
1. Marriott, J. B., Muller G., and Dalgleish, A.G., 1999, Thalidomide as an emerging immunotherapeutic agent. Immunol. Today 20 538-540. 2. Sampaio, E. P., Kaplan, G., Miranda, A., et al., 1993, The influence of thalidomide on the clinical and immunologic manifestation of erythema nodosum leprosum. J. Infect. Dis. 168 408-414. 3. Vogelsang, G.B., Santos, G.W., Colvin, O.M., et al., 1988, Thalidomide for graft-versus-host disease. Lancet I 827. 4. Lim, S.H., McWhannell, A., Vora, A.J., et al.,...
Discussion Wbn
In our BD patients, videocapillaroscopy showed several morphological and quantitative alterations of peripheral and conjunctival microvessels. Vessel alteration included changes both of the number and of the whole structure with an important rearrangement of microvascular disposition the presence of microaneurisms, desertification areas and flow change represent a severe vascular impairment which may be detected both in peripheral and conjunctival observation, exploring the two different...
Disease Activity Index
A disease activity index DAI has to be calculated for each section of each eye, at each visit. The calculation is based upon the inflammatory state of the eye. The severity of the inflammatory indices is graded from 0 to 4. These indices are determined as follows Anterior uveitis AU cells, flare, keratic precipitate and hypopyon in the anterior chamber. Posterior uveitis PU cells, snow ball and snow banking in the posterior chamber. Retinal vasculitis RV periarteritis, periphlebitis, edema of...
References Emg
1. Yazici, H., and Barnes, C.G., 1991, Practical treatment recommendations for pharmacotherapy of Behcet's syndrome. Drugs 42 796-804. 2. Zouboulis, Ch.C., and Orfanos, C.E., 1998, Treatment of Adamantiades-Beh et disease with systemic interferon alfa. Arch. Dermatol. 134 1010-1016. 3. Alpsoy, E., Durusoy, C., Yilmaz, E., et al., 2002, Interferon alfa-2a in the treatment of Behcet disease a randomized placebo-controlled and double-blind study. Arch. Dermatol. 138 467-471. 4. Stuebiger, N.,...
Materials And Methods Knj
Thirty-three eyes of 18 Behget patients, who were examined at the Ankara University Department of Ophthalmology between October 2000 and February 2002, were included in this study. Of the 18 patients, 11 were male and 7 were female. The patients were aged between 18-60 years mean age 32.4 . All of the patients were diagnosed by the Behget Center at Ankara University based on the diagnostic criteria for Behget's disease. All patients underwent a complete ocular examination, indirect...
Materials And Methods Vlm
Human vaginal mucosa was obtained from excess tissue removed from eight postmenopausal patients following vaginal hysterectomies. No specimens were obtained where there was clinical evidence of any disease that might have influenced the permeability characteristics of the vaginal mucosa. On arrival in our laboratory, excess connective tissue was trimmed away and all specimens were snap-frozen in liquid nitrogen and stored at -85 C for a period of up to 6 months10. The study was approved by the...
Results Jmn
Out of the 26 patients with bipolar aphthosis, 18 patients were female and 8 patients were male. The patients were 10 to 55 years of age mean age 32.69 years . The duration of follow-up ranged from 2 to 16 years, and the mean duration of follow-up per person was 5.50 years 5.55 SD . Age at the onset of oral ulcerations ranged from 6 to 52 years mean 25.42 and age at the onset of genital ulcerations ranged from 10 to 45 years mean 30 . During the follow-up period, 4 patients 15.3 had additional...
Fluorodeoxyglucose positron emission tomography
18Fluorodeoxyglucose positron emission tomography 1SF-FDG-PET as a nuclear medicine scintigraphic technique has been described for functional imaging of neoplastic and inflammatory processes in major organs like the central nervous system, heart, lung, gastrointestinum, and large vessels excluding the urinary bladder and the kidneys. Our experiences with FDG-PET for detection of hypermetabolism as a marker for inflammation in large arterial vessels are pointed out elsewhere in this book9....