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Institut de Biologie Moléculaire et Cellulaire, UPR9002 CNRS, Université Louis Pasteur, 67084 Strasbourg, France

6.1. Introduction 210

6.1.1. The Decoding "On" State of the Prokaryotic A-Site 210

6.1.2. The Decoding "On" State of the Prokaryotic A-Site Complexed with Aminoglycosides 215

6.1.3. The Decoding "On" State of the Eukaryotic Cytoplasmic A-Site 215

6.1.4. The Resting "Off" State of the Prokaryotic A-Site 216

6.1.5. The Resting "Off" State of the Eukaryotic Cytoplasmic A-Site 220

6.1.6. The Resting "Off" State of the Eukaryotic Cytoplasmic A-Site Complexed with the Aminoglycoside Apramycin 220

6.2. Conclusions 220 Acknowledgment 221 References 221

Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery, Second Edition, by Dev P. Arya Copyright © 2007 John Wiley & Sons, Inc.